Indian Journal of Public Health Research & Development

A. Julius ¹, K. Renugadevi ², S. Bhuminathan ³, S. Raghavendra Jayesh ⁴, Shobakishore ⁵

Affiliations
1 Department of Biochemistry, Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, IN
2 Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College,Venkatsennagar, IN
3 Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai,, IN
4 Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, IN
5 Department of Pathology, Sree Balaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai, IN

Abstract

Diabetes and aging are associated with reduced vascular endothelial function, 20 controls and 20 subjects with type 2 diabetes age 40 participated, a series of experiments were conducted to examine the interrelationship between age, Type 2 Diabetes Mellitus and endothelial renal function. This complication is first manifested as an increase in UAE [microalbuminuria] which progresses to over albuminuria and then to renal failure In subjects with diabetes age < 40 were more prone to nephropathy which progress to End Stage Renal Disease [ESRD]

Keywords

Diabetes Mellitus, Aging, Type 2 Diabetes Mellitus, ESRP, Nephropathy.

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B. Julius ¹, B. Durga ², S. Bhuminathan ³, Shobakishore ⁴, V. Ankayarkanni ⁵

Affiliations
1 Department of Biochemistry, Sree Balaji Dental College & Hospital Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Chennai, IN
2 Department of biochemistry, Prince Shri Venkateshwara Arts & Science College, Venkatesen Nagar, Chennai, IN
3 Department of Pronthodontics, Sree Balaji Dental College & Hospital, Narayanapuram, Chennai, IN
4 Department of Pathology, Sree Balaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai,, IN
5 Department of Physiology, Sree Balaji Dental College, Pallikaranai, Chennai. Bharath Institute of Higher Education and Research, IN

Abstract

Today millions of people die due to cigarette smoking in the world. Smoking is the most common method of consuming tobacco. Tobacco smoking is the practice of burning tobacco & inhaling the smoke Cigarette smoking is one major consequence to develop oxidative stress will damage the lung lead to death. Cigarette contains nicotinean addictive stimulant that causes psychological and physical dependency The aim of the study is to evaluate the oxidative stress by novel non-enzymatic antioxidant between young chronic smokers and non- smokers in the fasting state.

Keywords

Alpha tocopherol, PUFA,Vitamin C,β- Carotene, ROS, Smokers and Non –Smokers.

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A. Julius ¹, K. Renugadevi ², S. Bhuminathan ³, S. Raghavendra Jayesh ³, Shobakishore ⁴

Affiliations
1 Department of Biochemistry, Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, Chennai, IN
2 Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College,Venkatsennagar, Chennai, IN
3 Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, Chennai, IN
4 Department of Pathology, Sree Balaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai, IN

Abstract

Diabetes Nephropathy is a major microvascular complication of Diabetes Mellitus and the most common cause of End Stage Renal Disease (ESRD) worldwide. Hyperglycemia, a well recognized pathogentic factor of long term complications of Diabetes Mellitus, generates ROS. This attenuates antioxidative mechanisms through glycation of the scavenging enzymes. Excess amount of ROS modulate activation of protein kinaseC, mitogin activated protien kinares and various cytokines and transcription factors which eventually cause increased expression of extracellular matrix (ECM) genes with progression of fibrosis and end stage renal disease. Therefore, this study was carried out to investigate oxidant and antioxidant status in Diabetic patients for manifesting the progression to diabetic nephropathy.

Keywords

Diabetic Nephropathy, Hyperglycemia, Reactive Oxygem Species, Extracellular Matrix, Oxidative Stress.

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A. Julius ¹, K. Renugadevi ², S. Bhuminathan ³, S. RaghavendraJayesh ³, Shobakishore ⁴

Affiliations
1 Department of Biochemistry, SreeBalaji Dental College and Hospital Bharath Institute of HigherEducation and Research, (Bharath University),Narayanapuram, Pallikaranai, Chennai, IN
2 Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College,Venkatsennagar, Chennai, IN
3 Department of Prosthodontics, SreeBalaji Dental College and Hospital, Bharath Instituteof Higher Education and Research, (Bharath University),Narayanapuram, Pallikaranai, Chennai, IN
4 Department of Pathology, SreeBalaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai, IN

Abstract

Tamm Horsfall Protein or Uromodulin is the most abundant urinary glycoprotein that has a protective function in the bladder mucosal layer. THP is also the primary constituent of renal tubular casts and THP aggregation has been implicated as a factor in the pathogenesis of acute renal failure by causing tubular obstruction. Using ELISA, the autoantibody level of Tamm Horsfall Protein in serum was determined in Hypertensive Patients and control subjects. A significant percentage of hypertensive subjectshave a greater risk of renal stone formation, with high autoantibodies level to Tamm Horsfall Protein in serum when compared to control subjects. Hence THP acts as a potential biomarker for nephrolithiasis in Hypertensive patients.

Keywords

Tamm Horsfall Protein Hypertension ELISA Autoantibody Nephrolithiasis.

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